Drug interactions
Imipramine + Levosalbutamol
Severity: Moderate
Imipramine and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can potentiate the cardiovascular effects of beta-agonists such as levosalbutamol, with reports of tachycardia, palpitations and arrhythmia. Patients with heart disease are most at risk.
What this interaction means in plain words
Imipramine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Levosalbutamol belongs to Respiratory.
Why it happens
Tricyclics block norepinephrine reuptake and have additive adrenergic and QT-prolonging effects with beta-agonist-induced tachycardia and hypokalemia.
What to do
Monitor heart rate and rhythm, and obtain an ECG in patients with cardiac disease. Use the lowest effective levosalbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Levosalbutamol?
MediHelp rates the interaction as moderate. Imipramine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine can potentiate the cardiovascular effects of beta-agonists such as levosalbutamol, with reports of tachycardia, palpitations and arrhythmia. Patients with heart disease are most at risk.
How serious is the interaction between Imipramine and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm, and obtain an ECG in patients with cardiac disease. Use the lowest effective levosalbutamol dose.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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