Drug interactions
Imipramine + Liotrix
Severity: Moderate
Imipramine and Liotrix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liotrix contains levothyroxine and liothyronine, which may increase catecholamine sensitivity and enhance tricyclic effects. This can cause tachycardia, arrhythmias and CNS stimulation.
What this interaction means in plain words
Imipramine and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased adrenergic receptor sensitivity and pharmacodynamic synergy.
What to do
Monitor heart rate, ECG and mental state, especially in older patients or those with cardiac disease. Adjust doses based on thyroid function and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Liotrix?
MediHelp rates the interaction as moderate. Imipramine and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liotrix contains levothyroxine and liothyronine, which may increase catecholamine sensitivity and enhance tricyclic effects. This can cause tachycardia, arrhythmias and CNS stimulation.
How serious is the interaction between Imipramine and Liotrix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and mental state, especially in older patients or those with cardiac disease. Adjust doses based on thyroid function and clinical response.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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