Drug interactions
Imipramine + Loprazolam
Severity: Moderate
Imipramine and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines and sedating tricyclics together increase drowsiness, psychomotor impairment and fall risk. The effect is greatest in older people and at treatment initiation or dose increases.
What this interaction means in plain words
Imipramine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects through GABA-A potentiation and antihistaminic and anticholinergic actions of imipramine.
What to do
Use the lowest effective doses and the shortest duration, and counsel about sedation, driving and alcohol. Monitor older patients for falls and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Loprazolam?
MediHelp rates the interaction as moderate. Imipramine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines and sedating tricyclics together increase drowsiness, psychomotor impairment and fall risk. The effect is greatest in older people and at treatment initiation or dose increases.
How serious is the interaction between Imipramine and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and the shortest duration, and counsel about sedation, driving and alcohol. Monitor older patients for falls and confusion.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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