Drug interactions
Imipramine + Lormetazepam
Severity: Moderate
Imipramine and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam with imipramine can increase drowsiness, psychomotor impairment and fall risk. The effect is most pronounced in older patients and at dose changes.
What this interaction means in plain words
Imipramine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects through GABA-A potentiation and the sedative properties of imipramine.
What to do
Use the lowest effective doses and counsel patients on sedation, driving and alcohol. Monitor older patients for falls and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Lormetazepam?
MediHelp rates the interaction as moderate. Imipramine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam with imipramine can increase drowsiness, psychomotor impairment and fall risk. The effect is most pronounced in older patients and at dose changes.
How serious is the interaction between Imipramine and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients on sedation, driving and alcohol. Monitor older patients for falls and confusion.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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