Drug interactions
Imipramine + Loxapine inhaled
Severity: Moderate
Imipramine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine is systemically absorbed and can cause sedation and bronchospasm, while imipramine adds sedative, anticholinergic and QT effects. The combination may increase drowsiness, orthostatic hypotension and arrhythmia risk.
What this interaction means in plain words
Imipramine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, anticholinergic and QT-prolonging effects.
What to do
Monitor sedation and blood pressure after loxapine administration, and consider ECG in patients with cardiac risk factors. Use the inhaled product only under supervision with bronchodilator availability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Imipramine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine is systemically absorbed and can cause sedation and bronchospasm, while imipramine adds sedative, anticholinergic and QT effects. The combination may increase drowsiness, orthostatic hypotension and arrhythmia risk.
How serious is the interaction between Imipramine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure after loxapine administration, and consider ECG in patients with cardiac risk factors. Use the inhaled product only under supervision with bronchodilator availability.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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