Drug interactions
Imipramine + Lsd
Severity: Moderate
Imipramine and Lsd: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD acts on serotonin receptors, and tricyclic antidepressants may alter its effects, with both enhancement and attenuation reported. Serotonergic excess and unpredictable psychological or cardiovascular effects are possible.
What this interaction means in plain words
Imipramine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Overlapping serotonergic effects, with LSD 5-HT2A agonism and imipramine serotonin reuptake inhibition; the net effect is poorly characterized.
What to do
Advise against combining them, as LSD is an illicit drug. If exposure occurs, monitor for agitation, hyperthermia, tachycardia and signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Lsd?
MediHelp rates the interaction as moderate. Imipramine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD acts on serotonin receptors, and tricyclic antidepressants may alter its effects, with both enhancement and attenuation reported. Serotonergic excess and unpredictable psychological or cardiovascular effects are possible.
How serious is the interaction between Imipramine and Lsd?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against combining them, as LSD is an illicit drug. If exposure occurs, monitor for agitation, hyperthermia, tachycardia and signs of serotonin toxicity.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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