Drug interactions
Imipramine + Marijuana
Severity: Moderate
Imipramine and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis adds sedative effects and can cause tachycardia, and combined use with tricyclics has been linked to tachycardia, hypertension and delirium or agitation in case reports. Cannabinoids may also inhibit CYP2D6 and other enzymes, potentially raising tricyclic exposure.
What this interaction means in plain words
Imipramine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and sympathomimetic cardiovascular effects, with possible CYP inhibition by cannabinoids.
What to do
Advise patients to avoid or minimize cannabis use, and monitor heart rate, blood pressure and mental status if use continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Marijuana?
MediHelp rates the interaction as moderate. Imipramine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis adds sedative effects and can cause tachycardia, and combined use with tricyclics has been linked to tachycardia, hypertension and delirium or agitation in case reports. Cannabinoids may also inhibit CYP2D6 and other enzymes, potentially raising tricyclic exposure.
How serious is the interaction between Imipramine and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid or minimize cannabis use, and monitor heart rate, blood pressure and mental status if use continues.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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