Drug interactions
Imipramine + Meclizine
Severity: Moderate
Imipramine and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are anticholinergic, so combined use can produce excessive dry mouth, constipation, blurred vision, urinary retention and confusion, particularly in older adults. Sedation may also be increased.
What this interaction means in plain words
Imipramine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism and additive sedative antihistaminic effects.
What to do
Monitor for anticholinergic toxicity and sedation, and avoid the combination in elderly patients or those with glaucoma, urinary retention or dementia. Use the lowest effective meclizine dose or an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Meclizine
Frequently asked questions
Can I take Imipramine with Meclizine?
MediHelp rates the interaction as moderate. Imipramine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are anticholinergic, so combined use can produce excessive dry mouth, constipation, blurred vision, urinary retention and confusion, particularly in older adults. Sedation may also be increased.
How serious is the interaction between Imipramine and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, and avoid the combination in elderly patients or those with glaucoma, urinary retention or dementia. Use the lowest effective meclizine dose or an alternative.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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