Drug interactions
Imipramine + Metformin-sitagliptin
Severity: Minor
Imipramine and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may alter glycemic control and mask hypoglycemia in some patients. The effect with sitagliptin-metformin is small and inconsistent.
What this interaction means in plain words
Imipramine and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Possible additive glucose-lowering effect; the mechanism is not well established.
What to do
No routine adjustment is needed; monitor blood glucose when imipramine is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Imipramine and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may alter glycemic control and mask hypoglycemia in some patients. The effect with sitagliptin-metformin is small and inconsistent.
How serious is the interaction between Imipramine and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood glucose when imipramine is started or stopped.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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