Drug interactions
Imipramine + Methscopolamine
Severity: Moderate
Imipramine and Methscopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methscopolamine is an antimuscarinic that adds to the anticholinergic burden of imipramine. This can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia, with a risk of ileus or angle-closure glaucoma in susceptible patients.
What this interaction means in plain words
Imipramine and Methscopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity and reduce doses or switch to a non-anticholinergic alternative if symptoms develop. Be especially careful in older adults and those with glaucoma, urinary retention or constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Methscopolamine?
MediHelp rates the interaction as moderate. Imipramine and Methscopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methscopolamine is an antimuscarinic that adds to the anticholinergic burden of imipramine. This can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia, with a risk of ileus or angle-closure glaucoma in susceptible patients.
How serious is the interaction between Imipramine and Methscopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and reduce doses or switch to a non-anticholinergic alternative if symptoms develop. Be especially careful in older adults and those with glaucoma, urinary retention or constipation.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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