Drug interactions
Imipramine + Metoclopramide intranasal
Severity: Moderate
Imipramine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause extrapyramidal effects and, rarely, neuroleptic malignant syndrome, and tricyclics add anticholinergic and dopamine-modulating effects. Imipramine's CYP2D6 metabolism is also a minor factor, and metoclopramide is itself a weak CYP2D6 inhibitor, so concentrations of either drug may increase.
What this interaction means in plain words
Imipramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and extrapyramidal effects with opposing anticholinergic and prokinetic actions, plus possible CYP2D6 competition.
What to do
Monitor for extrapyramidal symptoms, sedation and reduced prokinetic effect. Use the lowest effective metoclopramide dose and consider an alternative if movement disorders develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imipramine and Metoclopramide intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Imipramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause extrapyramidal effects and, rarely, neuroleptic malignant syndrome, and tricyclics add anticholinergic and dopamine-modulating effects. Imipramine's CYP2D6 metabolism is also a minor factor, and metoclopramide is itself a weak CYP2D6 inhibitor, so concentrations of either drug may increase.
How serious is the interaction between Imipramine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and reduced prokinetic effect. Use the lowest effective metoclopramide dose and consider an alternative if movement disorders develop.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
