Drug interactions
Imipramine + Moxonidine
Severity: Moderate
Imipramine and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can reduce the antihypertensive effect of centrally acting alpha-2 or imidazoline agonists, and moxonidine labeling advises against concomitant use with tricyclics. Both can also cause sedation, and imipramine may blunt blood pressure control.
What this interaction means in plain words
Imipramine and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at central adrenergic and imidazoline receptors, plus additive sedation.
What to do
Monitor blood pressure closely and consider an alternative antihypertensive if control is lost. Watch for excess sedation and orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Moxonidine?
MediHelp rates the interaction as moderate. Imipramine and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can reduce the antihypertensive effect of centrally acting alpha-2 or imidazoline agonists, and moxonidine labeling advises against concomitant use with tricyclics. Both can also cause sedation, and imipramine may blunt blood pressure control.
How serious is the interaction between Imipramine and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and consider an alternative antihypertensive if control is lost. Watch for excess sedation and orthostatic hypotension.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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