Drug interactions
Imipramine + Octreotide
Severity: Moderate
Imipramine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of imipramine. The risk is greatest with bradycardia, electrolyte disturbance or heart disease.
What this interaction means in plain words
Imipramine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia increasing arrhythmia susceptibility.
What to do
Check baseline ECG and electrolytes and monitor heart rate and QTc during treatment, especially in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Imipramine with Octreotide?
MediHelp rates the interaction as moderate. Imipramine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of imipramine. The risk is greatest with bradycardia, electrolyte disturbance or heart disease.
How serious is the interaction between Imipramine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor heart rate and QTc during treatment, especially in patients with cardiac disease.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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