Drug interactions
Imipramine + Olodaterol inhaled
Severity: Moderate
Imipramine and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta2 agonists such as olodaterol, including tachycardia, palpitations and QT prolongation. This may raise the risk of ventricular arrhythmias, particularly in patients with underlying heart disease or electrolyte disturbances.
What this interaction means in plain words
Imipramine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cardiac effects: TCA-related QT prolongation and noradrenergic effects combined with beta2-agonist-induced tachycardia and hypokalemia.
What to do
Monitor heart rate, ECG (QTc) and potassium in patients with cardiac risk factors. Consider an alternative bronchodilator if QTc prolongation or arrhythmia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imipramine and Olodaterol inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Imipramine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta2 agonists such as olodaterol, including tachycardia, palpitations and QT prolongation. This may raise the risk of ventricular arrhythmias, particularly in patients with underlying heart disease or electrolyte disturbances.
How serious is the interaction between Imipramine and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG (QTc) and potassium in patients with cardiac risk factors. Consider an alternative bronchodilator if QTc prolongation or arrhythmia develops.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
