Drug interactions
Imipramine + Olopatadine intranasal
Severity: Moderate
Imipramine and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine is a sedating antihistamine, and combination with imipramine can add to drowsiness and psychomotor impairment. Imipramine's anticholinergic effects may also add to dryness and confusion.
What this interaction means in plain words
Imipramine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antihistaminic effects (pharmacodynamic).
What to do
Advise patients to avoid driving and hazardous tasks until response is known, and avoid alcohol. Reduce the olopatadine dose or choose a nonsedating alternative if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Imipramine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine is a sedating antihistamine, and combination with imipramine can add to drowsiness and psychomotor impairment. Imipramine's anticholinergic effects may also add to dryness and confusion.
How serious is the interaction between Imipramine and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and hazardous tasks until response is known, and avoid alcohol. Reduce the olopatadine dose or choose a nonsedating alternative if drowsiness is troublesome.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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