Drug interactions
Imipramine + Oxybutynin transdermal
Severity: Moderate
Imipramine and Oxybutynin transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine has substantial anticholinergic activity that can add to the effects of oxybutynin, even when absorbed through the skin. This may lead to dry mouth, constipation, urinary retention, blurred vision and cognitive impairment.
What this interaction means in plain words
Imipramine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects at peripheral and central receptors.
What to do
Monitor for anticholinergic adverse effects and cognitive changes, especially in older patients. Consider a less anticholinergic option for either condition if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Oxybutynin transdermal?
MediHelp rates the interaction as moderate. Imipramine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine has substantial anticholinergic activity that can add to the effects of oxybutynin, even when absorbed through the skin. This may lead to dry mouth, constipation, urinary retention, blurred vision and cognitive impairment.
How serious is the interaction between Imipramine and Oxybutynin transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and cognitive changes, especially in older patients. Consider a less anticholinergic option for either condition if effects emerge.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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