Drug interactions
Imipramine + Parecoxib
Severity: Minor
Imipramine and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is metabolised by CYP2C19 and CYP3A4 and may modestly affect CYP2D6 substrates. A clinically meaningful rise in imipramine levels is possible but not well documented, and any increase would be modest.
What this interaction means in plain words
Imipramine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP2D6 and CYP2C19 metabolism of imipramine; not firmly established.
What to do
No routine dose change is needed; monitor for tricyclic adverse effects such as anticholinergic symptoms and tachycardia if therapy is combined.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imipramine and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Parecoxib?
MediHelp rates the interaction as minor. Imipramine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, which is metabolised by CYP2C19 and CYP3A4 and may modestly affect CYP2D6 substrates. A clinically meaningful rise in imipramine levels is possible but not well documented, and any increase would be modest.
How serious is the interaction between Imipramine and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for tricyclic adverse effects such as anticholinergic symptoms and tachycardia if therapy is combined.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
