Drug interactions
Imipramine + Pipemidic acid
Severity: Moderate
Imipramine and Pipemidic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pipemidic acid is a quinolone that inhibits CYP1A2 and may increase imipramine concentrations, as demonstrated with related quinolones. Higher levels could increase anticholinergic effects, sedation and cardiac toxicity.
What this interaction means in plain words
Imipramine and Pipemidic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2-mediated imipramine N-demethylation.
What to do
Monitor for tricyclic adverse effects and consider an ECG in patients with cardiac risk. Reduce imipramine dose if toxicity develops, or use a different antibacterial.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Pipemidic acid?
MediHelp rates the interaction as moderate. Imipramine and Pipemidic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pipemidic acid is a quinolone that inhibits CYP1A2 and may increase imipramine concentrations, as demonstrated with related quinolones. Higher levels could increase anticholinergic effects, sedation and cardiac toxicity.
How serious is the interaction between Imipramine and Pipemidic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider an ECG in patients with cardiac risk. Reduce imipramine dose if toxicity develops, or use a different antibacterial.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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