Drug interactions
Imipramine + Pirbuterol
Severity: Moderate
Imipramine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine may heighten the cardiovascular response to pirbuterol, leading to tachycardia, palpitations or arrhythmia. Labeling for beta-agonists advises caution with tricyclics.
What this interaction means in plain words
Imipramine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics inhibit noradrenaline reuptake and may potentiate beta-agonist cardiovascular effects.
What to do
Monitor heart rate, rhythm and blood pressure, and use the lowest effective pirbuterol dose. Choose another bronchodilator if cardiac adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Pirbuterol?
MediHelp rates the interaction as moderate. Imipramine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine may heighten the cardiovascular response to pirbuterol, leading to tachycardia, palpitations or arrhythmia. Labeling for beta-agonists advises caution with tricyclics.
How serious is the interaction between Imipramine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, and use the lowest effective pirbuterol dose. Choose another bronchodilator if cardiac adverse effects occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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