Drug interactions
Imipramine + Promazine
Severity: Major
Imipramine and Promazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both phenothiazines and tricyclics prolong the QT interval, so combined use increases the risk of torsades de pointes. Additive anticholinergic and sedative effects and mutual metabolic inhibition via CYP2D6 may also raise concentrations.
What this interaction means in plain words
Imipramine and Promazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and anticholinergic and sedative effects, with possible CYP2D6 competition.
What to do
Avoid if alternatives exist. If combined, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Promazine?
MediHelp rates the interaction as major. Imipramine and Promazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both phenothiazines and tricyclics prolong the QT interval, so combined use increases the risk of torsades de pointes. Additive anticholinergic and sedative effects and mutual metabolic inhibition via CYP2D6 may also raise concentrations.
How serious is the interaction between Imipramine and Promazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist. If combined, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor for sedation and anticholinergic effects.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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