Drug interactions
Imipramine + Remimazolam
Severity: Major
Imipramine and Remimazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam given with other CNS depressants such as imipramine can cause deeper than intended sedation and respiratory depression. Hypotension and delayed recovery are also possible.
What this interaction means in plain words
Imipramine and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imipramine belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression through GABA-A potentiation and the sedating effects of imipramine.
What to do
Titrate remimazolam carefully to effect, with continuous monitoring of oxygen saturation, respiration and blood pressure by trained staff. Reduce the dose in older or frail patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Imipramine with Remimazolam?
MediHelp rates the interaction as major. Imipramine and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam given with other CNS depressants such as imipramine can cause deeper than intended sedation and respiratory depression. Hypotension and delayed recovery are also possible.
How serious is the interaction between Imipramine and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully to effect, with continuous monitoring of oxygen saturation, respiration and blood pressure by trained staff. Reduce the dose in older or frail patients.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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