Drug interactions
Imipramine + Same
Severity: Moderate
Imipramine and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine may boost serotonergic neurotransmission, and imipramine inhibits serotonin reuptake. Combining them could increase the risk of serotonin toxicity, although reports are limited.
What this interaction means in plain words
Imipramine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from increased serotonin turnover and reuptake inhibition.
What to do
Monitor for agitation, tremor, sweating, diarrhea and clonus after starting or increasing either agent. Stop SAMe if serotonin toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Same?
MediHelp rates the interaction as moderate. Imipramine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine may boost serotonergic neurotransmission, and imipramine inhibits serotonin reuptake. Combining them could increase the risk of serotonin toxicity, although reports are limited.
How serious is the interaction between Imipramine and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, sweating, diarrhea and clonus after starting or increasing either agent. Stop SAMe if serotonin toxicity develops.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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