Drug interactions
Imipramine + Scullcap
Severity: Minor
Imipramine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap has traditional sedative effects, so combining it with imipramine may increase drowsiness. Evidence is based on theory and traditional use rather than clinical studies.
What this interaction means in plain words
Imipramine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; not well characterised.
What to do
Advise patients to report excessive drowsiness and avoid driving if sedated. Consider avoiding the herbal product if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Scullcap?
MediHelp rates the interaction as minor. Imipramine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap has traditional sedative effects, so combining it with imipramine may increase drowsiness. Evidence is based on theory and traditional use rather than clinical studies.
How serious is the interaction between Imipramine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report excessive drowsiness and avoid driving if sedated. Consider avoiding the herbal product if sedation is troublesome.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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