Drug interactions
Imipramine + Selegiline transdermal
Severity: Contraindicated
Imipramine and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline at antidepressant doses inhibits MAO, and combining it with a tricyclic can cause serotonin syndrome or hypertensive reactions. The labeling contraindicates its use with tricyclic antidepressants.
What this interaction means in plain words
Imipramine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition by selegiline combined with imipramine reuptake inhibition of serotonin and norepinephrine.
What to do
Do not coadminister. Allow at least two weeks after stopping selegiline before starting imipramine, and wait an adequate washout after stopping imipramine before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imipramine and Selegiline transdermal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Imipramine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Transdermal selegiline at antidepressant doses inhibits MAO, and combining it with a tricyclic can cause serotonin syndrome or hypertensive reactions. The labeling contraindicates its use with tricyclic antidepressants.
How serious is the interaction between Imipramine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least two weeks after stopping selegiline before starting imipramine, and wait an adequate washout after stopping imipramine before starting selegiline.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
