Drug interactions
Imipramine + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Imipramine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can cause SIADH-type hyponatremia in some patients, and osmotic bowel preparations cause fluid and electrolyte shifts. Together they may increase the risk of water retention, hyponatremia and related seizures.
What this interaction means in plain words
Imipramine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on water and electrolyte balance, with imipramine-associated SIADH and bowel prep fluid shifts.
What to do
Encourage appropriate hydration with the prep and avoid excess free water. Check sodium in older or high-risk patients and if symptoms such as confusion or nausea develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Imipramine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine can cause SIADH-type hyponatremia in some patients, and osmotic bowel preparations cause fluid and electrolyte shifts. Together they may increase the risk of water retention, hyponatremia and related seizures.
How serious is the interaction between Imipramine and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Encourage appropriate hydration with the prep and avoid excess free water. Check sodium in older or high-risk patients and if symptoms such as confusion or nausea develop.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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