Drug interactions
Imipramine + Sufentanil sl
Severity: Moderate
Imipramine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity combined with tricyclic antidepressants carry a small risk of serotonin syndrome. Additive sedation and respiratory depression also occur.
What this interaction means in plain words
Imipramine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from imipramine reuptake inhibition and opioid activity, plus additive CNS depression.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and sedation, especially when starting or increasing doses. Stop the combination if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Sufentanil sl?
MediHelp rates the interaction as moderate. Imipramine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids with serotonergic activity combined with tricyclic antidepressants carry a small risk of serotonin syndrome. Additive sedation and respiratory depression also occur.
How serious is the interaction between Imipramine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and sedation, especially when starting or increasing doses. Stop the combination if serotonin syndrome is suspected.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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