Drug interactions
Imipramine + Sumatriptan intranasal
Severity: Moderate
Imipramine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans and serotonergic antidepressants have been associated with serotonin syndrome, although the actual risk appears low. Symptoms can include agitation, tremor, hyperthermia and autonomic instability.
What this interaction means in plain words
Imipramine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism and serotonin reuptake inhibition.
What to do
Counsel the patient on the symptoms of serotonin syndrome and monitor after starting or increasing doses. Stop sumatriptan if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Imipramine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans and serotonergic antidepressants have been associated with serotonin syndrome, although the actual risk appears low. Symptoms can include agitation, tremor, hyperthermia and autonomic instability.
How serious is the interaction between Imipramine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on the symptoms of serotonin syndrome and monitor after starting or increasing doses. Stop sumatriptan if symptoms appear.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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