Drug interactions
Imipramine + Thiothixene
Severity: Moderate
Imipramine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and anticholinergic effects, and tricyclics can raise antipsychotic levels. Together they also lower the seizure threshold and may prolong the QT interval.
What this interaction means in plain words
Imipramine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, anticholinergic and seizure-threshold effects, with possible CYP2D6-related pharmacokinetic competition.
What to do
Use the lowest effective doses and monitor for sedation, anticholinergic effects and orthostasis. Consider an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Thiothixene?
MediHelp rates the interaction as moderate. Imipramine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and anticholinergic effects, and tricyclics can raise antipsychotic levels. Together they also lower the seizure threshold and may prolong the QT interval.
How serious is the interaction between Imipramine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, anticholinergic effects and orthostasis. Consider an ECG in patients with cardiac risk factors.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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