Drug interactions
Imipramine + Thyroid desiccated
Severity: Moderate
Imipramine and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone can enhance the response to tricyclic antidepressants and may speed their effect, but also increases the risk of cardiac arrhythmias and CNS stimulation.
What this interaction means in plain words
Imipramine and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases adrenergic receptor sensitivity, potentiating the noradrenergic effects of imipramine.
What to do
Monitor heart rate, rhythm and signs of agitation or thyrotoxicosis. Adjust the dose of either drug and obtain an ECG if palpitations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Thyroid desiccated?
MediHelp rates the interaction as moderate. Imipramine and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone can enhance the response to tricyclic antidepressants and may speed their effect, but also increases the risk of cardiac arrhythmias and CNS stimulation.
How serious is the interaction between Imipramine and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and signs of agitation or thyrotoxicosis. Adjust the dose of either drug and obtain an ECG if palpitations occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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