Drug interactions
Imipramine + Topiramate
Severity: Moderate
Imipramine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and cognitive slowing, which can be additive. Topiramate may also add to anticholinergic-type or metabolic effects in some patients.
What this interaction means in plain words
Imipramine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of the two agents.
What to do
Titrate slowly and monitor for drowsiness, confusion and impaired concentration; counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Imipramine with Topiramate?
MediHelp rates the interaction as moderate. Imipramine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and cognitive slowing, which can be additive. Topiramate may also add to anticholinergic-type or metabolic effects in some patients.
How serious is the interaction between Imipramine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate slowly and monitor for drowsiness, confusion and impaired concentration; counsel patients about driving.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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