Drug interactions
Imipramine + Triprolidine
Severity: Moderate
Imipramine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a strongly sedating and anticholinergic tricyclic antidepressant, and triprolidine adds to both effects. The combination may cause marked drowsiness, dry mouth, constipation, urinary retention, blurred vision and confusion.
What this interaction means in plain words
Imipramine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression and additive antimuscarinic effects.
What to do
Monitor for sedation and anticholinergic toxicity, particularly in older patients or those with glaucoma or prostatic hypertrophy. Consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Triprolidine?
MediHelp rates the interaction as moderate. Imipramine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a strongly sedating and anticholinergic tricyclic antidepressant, and triprolidine adds to both effects. The combination may cause marked drowsiness, dry mouth, constipation, urinary retention, blurred vision and confusion.
How serious is the interaction between Imipramine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic toxicity, particularly in older patients or those with glaucoma or prostatic hypertrophy. Consider a non-sedating antihistamine as an alternative.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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