Drug interactions
Imipramine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Imipramine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of the beta-agonist vilanterol, causing tachycardia, palpitations, hypertension and arrhythmias. Labeling advises extreme caution during use or within two weeks of stopping a tricyclic. Umeclidinium adds anticholinergic effects that may be additive with imipramine.
What this interaction means in plain words
Imipramine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics block norepinephrine reuptake and may potentiate the vascular and cardiac effects of beta-agonists, with additive anticholinergic activity from umeclidinium.
What to do
Monitor heart rate, blood pressure and ECG if needed, and watch for palpitations or arrhythmia. Consider an alternative bronchodilator if cardiovascular effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Imipramine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of the beta-agonist vilanterol, causing tachycardia, palpitations, hypertension and arrhythmias. Labeling advises extreme caution during use or within two weeks of stopping a tricyclic. Umeclidinium adds anticholinergic effects that may be additive with imipramine.
How serious is the interaction between Imipramine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG if needed, and watch for palpitations or arrhythmia. Consider an alternative bronchodilator if cardiovascular effects emerge.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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