Drug interactions
Imipramine + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Imipramine and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of vilanterol, a long-acting beta-agonist. This may produce tachycardia, palpitations, blood pressure changes and arrhythmias. Labeling advises extreme caution during tricyclic therapy and for two weeks after stopping.
What this interaction means in plain words
Imipramine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics inhibit norepinephrine reuptake and may enhance the vascular and cardiac responses to beta-agonists.
What to do
Monitor heart rate, blood pressure and symptoms of arrhythmia, particularly when starting or increasing doses. Consider an alternative inhaled therapy in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Imipramine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of vilanterol, a long-acting beta-agonist. This may produce tachycardia, palpitations, blood pressure changes and arrhythmias. Labeling advises extreme caution during tricyclic therapy and for two weeks after stopping.
How serious is the interaction between Imipramine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and symptoms of arrhythmia, particularly when starting or increasing doses. Consider an alternative inhaled therapy in patients with cardiac disease.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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