Drug interactions
Imipramine + Xylometazoline
Severity: Moderate
Imipramine and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine blocks norepinephrine reuptake and may potentiate the pressor effects of sympathomimetics. Intranasal xylometazoline has low systemic absorption, so effects are usually small, but overuse could raise blood pressure or provoke arrhythmia.
What this interaction means in plain words
Imipramine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Xylometazoline belongs to Respiratory.
Why it happens
Tricyclic inhibition of norepinephrine reuptake enhances adrenergic responses to vasoconstrictors.
What to do
Limit xylometazoline to the lowest dose for a few days. Monitor blood pressure and heart rate in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Xylometazoline?
MediHelp rates the interaction as moderate. Imipramine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine blocks norepinephrine reuptake and may potentiate the pressor effects of sympathomimetics. Intranasal xylometazoline has low systemic absorption, so effects are usually small, but overuse could raise blood pressure or provoke arrhythmia.
How serious is the interaction between Imipramine and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit xylometazoline to the lowest dose for a few days. Monitor blood pressure and heart rate in patients with cardiovascular disease.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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