Drug interactions
Immune globulin + Measles mumps and rubella vaccine
Severity: Moderate
Immune globulin and Measles mumps and rubella vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intramuscular immune globulin contains measles-specific antibodies that can neutralize the live vaccine virus. Vaccine-induced immunity may be reduced or fail to develop.
What this interaction means in plain words
Immune globulin and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passive antibodies neutralize live attenuated measles, mumps and rubella viruses, impairing vaccine replication and immune response.
What to do
Delay MMR vaccination after immune globulin according to the dose-dependent interval in immunization guidelines. If the vaccine was given first, wait about 2 weeks before giving immune globulin, otherwise revaccinate after the appropriate interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Immune globulin with Measles mumps and rubella vaccine?
MediHelp rates the interaction as moderate. Immune globulin and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intramuscular immune globulin contains measles-specific antibodies that can neutralize the live vaccine virus. Vaccine-induced immunity may be reduced or fail to develop.
How serious is the interaction between Immune globulin and Measles mumps and rubella vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay MMR vaccination after immune globulin according to the dose-dependent interval in immunization guidelines. If the vaccine was given first, wait about 2 weeks before giving immune globulin, otherwise revaccinate after the appropriate interval.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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