Drug interactions
Immune globulin sc + Measles mumps and rubella vaccine
Severity: Moderate
Immune globulin sc and Measles mumps and rubella vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Subcutaneous immune globulin supplies pooled antibodies, including those against measles, mumps and rubella, that can neutralize live vaccine viruses. Seroconversion after MMR may therefore be diminished.
What this interaction means in plain words
Immune globulin sc and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively acquired antibodies neutralize live vaccine virus and reduce its replication and immunogenicity.
What to do
Follow immunization guidance on timing live vaccines relative to immune globulin, and consider serologic confirmation of immunity or revaccination in patients on regular replacement therapy. Patients with primary immunodeficiency needing replacement immune globulin generally should not receive live vaccines at all.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Immune globulin sc with Measles mumps and rubella vaccine?
MediHelp rates the interaction as moderate. Immune globulin sc and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Subcutaneous immune globulin supplies pooled antibodies, including those against measles, mumps and rubella, that can neutralize live vaccine viruses. Seroconversion after MMR may therefore be diminished.
How serious is the interaction between Immune globulin sc and Measles mumps and rubella vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow immunization guidance on timing live vaccines relative to immune globulin, and consider serologic confirmation of immunity or revaccination in patients on regular replacement therapy. Patients with primary immunodeficiency needing replacement immune globulin generally should not receive live vaccines at all.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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