Drug interactions
Incobotulinumtoxina + Promethazine
Severity: Minor
Incobotulinumtoxina and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergic drugs may theoretically add to the effects of botulinum toxin, with a risk of excessive neuromuscular weakness or increased systemic anticholinergic effects. Clinically significant effects are uncommon at usual cosmetic or therapeutic doses.
What this interaction means in plain words
Incobotulinumtoxina and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive reduction in cholinergic neurotransmission, with toxin blocking acetylcholine release and promethazine blocking muscarinic receptors.
What to do
Monitor for unusual muscle weakness, swallowing or breathing difficulty after injection, particularly with high toxin doses. No dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Incobotulinumtoxina with Promethazine?
MediHelp rates the interaction as minor. Incobotulinumtoxina and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anticholinergic drugs may theoretically add to the effects of botulinum toxin, with a risk of excessive neuromuscular weakness or increased systemic anticholinergic effects. Clinically significant effects are uncommon at usual cosmetic or therapeutic doses.
How serious is the interaction between Incobotulinumtoxina and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for unusual muscle weakness, swallowing or breathing difficulty after injection, particularly with high toxin doses. No dose change is routinely needed.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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