Drug interactions
Incobotulinumtoxina + Tobramycin
Severity: Moderate
Incobotulinumtoxina and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can impair neuromuscular transmission and may add to the effect of botulinum toxin. This can cause excessive or generalized muscle weakness, including swallowing and breathing difficulty.
What this interaction means in plain words
Incobotulinumtoxina and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of neuromuscular transmission, via reduced presynaptic acetylcholine release by aminoglycosides and toxin-induced blockade.
What to do
Monitor for generalized weakness, dysphagia and respiratory compromise after injection. Avoid giving systemic tobramycin around the time of injection when alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Incobotulinumtoxina with Tobramycin?
MediHelp rates the interaction as moderate. Incobotulinumtoxina and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can impair neuromuscular transmission and may add to the effect of botulinum toxin. This can cause excessive or generalized muscle weakness, including swallowing and breathing difficulty.
How serious is the interaction between Incobotulinumtoxina and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for generalized weakness, dysphagia and respiratory compromise after injection. Avoid giving systemic tobramycin around the time of injection when alternatives exist.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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