Drug interactions
Incobotulinumtoxina + Tolterodine
Severity: Moderate
Incobotulinumtoxina and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic anticholinergics may add to the effects of botulinum toxin. This could increase distant neuromuscular weakness or anticholinergic adverse effects, though the risk with local injections is low.
What this interaction means in plain words
Incobotulinumtoxina and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cholinergic blockade at the neuromuscular junction and muscarinic receptors.
What to do
Monitor for excessive weakness, swallowing or breathing difficulty and anticholinergic effects after injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Incobotulinumtoxina with Tolterodine?
MediHelp rates the interaction as moderate. Incobotulinumtoxina and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic anticholinergics may add to the effects of botulinum toxin. This could increase distant neuromuscular weakness or anticholinergic adverse effects, though the risk with local injections is low.
How serious is the interaction between Incobotulinumtoxina and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive weakness, swallowing or breathing difficulty and anticholinergic effects after injection.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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