Drug interactions
Indacaterol inhaled + Ketoconazole
Severity: Minor
Indacaterol inhaled and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases systemic exposure to inhaled indacaterol. At the usual recommended dose this increase has been well tolerated, but beta-agonist effects such as tachycardia, tremor and hypokalemia are possible.
What this interaction means in plain words
Indacaterol inhaled and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ketoconazole inhibits CYP3A4 and P-glycoprotein, reducing the systemic clearance of indacaterol.
What to do
No dose adjustment is needed at the recommended indacaterol dose; monitor heart rate and symptoms of beta-agonist excess, and potassium if risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Ketoconazole?
MediHelp rates the interaction as minor. Indacaterol inhaled and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole increases systemic exposure to inhaled indacaterol. At the usual recommended dose this increase has been well tolerated, but beta-agonist effects such as tachycardia, tremor and hypokalemia are possible.
How serious is the interaction between Indacaterol inhaled and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed at the recommended indacaterol dose; monitor heart rate and symptoms of beta-agonist excess, and potassium if risk factors exist.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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