Drug interactions
Indacaterol inhaled + Methadone
Severity: Moderate
Indacaterol inhaled and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can prolong the QT interval at high doses, and methadone has a clear dose-related QT effect. Together they may modestly raise the risk of arrhythmia, and beta-agonist hypokalemia may add to it.
What this interaction means in plain words
Indacaterol inhaled and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia and sympathetic stimulation adding to methadone hERG blockade.
What to do
Use the usual indacaterol dose and monitor the ECG in patients on higher methadone doses or with cardiac risk factors. Check potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Methadone?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol can prolong the QT interval at high doses, and methadone has a clear dose-related QT effect. Together they may modestly raise the risk of arrhythmia, and beta-agonist hypokalemia may add to it.
How serious is the interaction between Indacaterol inhaled and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the usual indacaterol dose and monitor the ECG in patients on higher methadone doses or with cardiac risk factors. Check potassium and magnesium.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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