Drug interactions
Indacaterol inhaled + Nortriptyline
Severity: Moderate
Indacaterol inhaled and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta-agonists, including QT prolongation and arrhythmias. Indacaterol may also cause hypokalemia and tachycardia, adding to the risk.
What this interaction means in plain words
Indacaterol inhaled and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects.
What to do
Monitor heart rate, ECG and potassium in patients with cardiac risk factors. Use the lowest effective doses of both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Nortriptyline?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta-agonists, including QT prolongation and arrhythmias. Indacaterol may also cause hypokalemia and tachycardia, adding to the risk.
How serious is the interaction between Indacaterol inhaled and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium in patients with cardiac risk factors. Use the lowest effective doses of both drugs.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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