Drug interactions
Indacaterol inhaled + Ofloxacin
Severity: Moderate
Indacaterol inhaled and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin can modestly prolong the QT interval, and high systemic exposure to beta2-agonists such as indacaterol can add to cardiac effects including QT prolongation and hypokalemia. Together they may slightly raise the risk of ventricular arrhythmia, mainly in patients with other risk factors.
What this interaction means in plain words
Indacaterol inhaled and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization (fluoroquinolone hERG blockade plus beta2-agonist-related QT effects and hypokalemia).
What to do
Check baseline ECG and potassium and magnesium in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs. Correct electrolyte abnormalities and consider a non-QT-prolonging antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Indacaterol inhaled with Ofloxacin?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin can modestly prolong the QT interval, and high systemic exposure to beta2-agonists such as indacaterol can add to cardiac effects including QT prolongation and hypokalemia. Together they may slightly raise the risk of ventricular arrhythmia, mainly in patients with other risk factors.
How serious is the interaction between Indacaterol inhaled and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium and magnesium in patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs. Correct electrolyte abnormalities and consider a non-QT-prolonging antibiotic in high-risk patients.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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