Drug interactions
Indacaterol inhaled + Phenelzine
Severity: Moderate
Indacaterol inhaled and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol labeling advises extreme caution with MAO inhibitors because the cardiovascular effects of beta2 agonists may be potentiated. This can increase heart rate, blood pressure and arrhythmia risk, including QTc effects.
What this interaction means in plain words
Indacaterol inhaled and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition potentiates sympathomimetic cardiovascular effects of the beta2 agonist.
What to do
Monitor heart rate, blood pressure and arrhythmia symptoms, and consider ECG in patients with cardiac disease. Use the lowest effective indacaterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Phenelzine?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol labeling advises extreme caution with MAO inhibitors because the cardiovascular effects of beta2 agonists may be potentiated. This can increase heart rate, blood pressure and arrhythmia risk, including QTc effects.
How serious is the interaction between Indacaterol inhaled and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and arrhythmia symptoms, and consider ECG in patients with cardiac disease. Use the lowest effective indacaterol dose.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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