Drug interactions
Indacaterol inhaled + Timolol
Severity: Major
Indacaterol inhaled and Timolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol is a nonselective beta-blocker and can antagonize the bronchodilator action of indacaterol. It may also provoke severe bronchospasm in patients with COPD or asthma, even in ophthalmic form.
What this interaction means in plain words
Indacaterol inhaled and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competitive antagonism at beta-2 adrenergic receptors by timolol, opposing the beta-2 agonist indacaterol.
What to do
Avoid nonselective beta-blockers in patients using long-acting beta-agonists for obstructive airway disease. If a beta-blocker is essential, use a cardioselective agent with close respiratory monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Indacaterol inhaled with Timolol?
MediHelp rates the interaction as major. Indacaterol inhaled and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Timolol is a nonselective beta-blocker and can antagonize the bronchodilator action of indacaterol. It may also provoke severe bronchospasm in patients with COPD or asthma, even in ophthalmic form.
How serious is the interaction between Indacaterol inhaled and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers in patients using long-acting beta-agonists for obstructive airway disease. If a beta-blocker is essential, use a cardioselective agent with close respiratory monitoring.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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