Drug interactions
Indapamide + Insulin degludec-liraglutide
Severity: Minor
Indapamide and Insulin degludec-liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, can raise blood glucose and reduce the effect of insulin and liraglutide. Its metabolic effect is usually small at low doses.
What this interaction means in plain words
Indapamide and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Diuretic-related hypokalemia and reduced insulin sensitivity cause pharmacodynamic antagonism.
What to do
Monitor glucose and potassium when indapamide is started or the dose increased. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Insulin degludec-liraglutide?
MediHelp rates the interaction as minor. Indapamide and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide, a thiazide-like diuretic, can raise blood glucose and reduce the effect of insulin and liraglutide. Its metabolic effect is usually small at low doses.
How serious is the interaction between Indapamide and Insulin degludec-liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and potassium when indapamide is started or the dose increased. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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