Drug interactions
Indapamide + Lofexidine
Severity: Moderate
Indapamide and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers heart rate and blood pressure, and indapamide adds to the blood pressure lowering. Indapamide-induced electrolyte disturbances may increase lofexidine QT risk.
What this interaction means in plain words
Indapamide and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effect (pharmacodynamic), plus electrolyte disturbance that may worsen QT risk.
What to do
Monitor blood pressure, heart rate and electrolytes, correcting potassium and magnesium. Reduce the dose or adjust the antihypertensive regimen if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indapamide and Lofexidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Indapamide with Lofexidine?
MediHelp rates the interaction as moderate. Indapamide and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers heart rate and blood pressure, and indapamide adds to the blood pressure lowering. Indapamide-induced electrolyte disturbances may increase lofexidine QT risk.
How serious is the interaction between Indapamide and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and electrolytes, correcting potassium and magnesium. Reduce the dose or adjust the antihypertensive regimen if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
