Drug interactions
Indapamide + Metformin-pioglitazone
Severity: Minor
Indapamide and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic that can modestly impair glucose tolerance, partly opposing the antidiabetic effect. The effect at usual low doses is generally small.
What this interaction means in plain words
Indapamide and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Diuretic-related hypokalemia and reduced insulin sensitivity increase blood glucose.
What to do
Monitor blood glucose and potassium, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Indapamide and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide is a thiazide-like diuretic that can modestly impair glucose tolerance, partly opposing the antidiabetic effect. The effect at usual low doses is generally small.
How serious is the interaction between Indapamide and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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