Drug interactions
Indapamide + Methadone
Severity: Major
Indapamide and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can cause hypokalemia and hypomagnesemia and has QT-prolonging potential, while methadone prolongs QTc directly. The combination raises the risk of torsades de pointes.
What this interaction means in plain words
Indapamide and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indapamide belongs to Cardiovascular; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation, with diuretic-induced electrolyte loss increasing arrhythmia susceptibility.
What to do
Monitor potassium and magnesium and replace deficits, and check the ECG at baseline and after changes. Consider a different antihypertensive if the QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Methadone?
MediHelp rates the interaction as major. Indapamide and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indapamide can cause hypokalemia and hypomagnesemia and has QT-prolonging potential, while methadone prolongs QTc directly. The combination raises the risk of torsades de pointes.
How serious is the interaction between Indapamide and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium and replace deficits, and check the ECG at baseline and after changes. Consider a different antihypertensive if the QTc lengthens.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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