Drug interactions
Indapamide + Naproxen
Severity: Moderate
Indapamide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen may reduce the antihypertensive effect of indapamide and, in volume-depleted or elderly patients, increase the risk of renal impairment.
What this interaction means in plain words
Indapamide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and fluid retention and reduces renal perfusion, opposing diuretic action.
What to do
Monitor blood pressure and renal function, keep the patient hydrated, and use the lowest effective naproxen dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Naproxen?
MediHelp rates the interaction as moderate. Indapamide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen may reduce the antihypertensive effect of indapamide and, in volume-depleted or elderly patients, increase the risk of renal impairment.
How serious is the interaction between Indapamide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function, keep the patient hydrated, and use the lowest effective naproxen dose for the shortest time.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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